February 15, 2026
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Granulation tissue is composed of tissue matrix supporting a variety of cell types, [3] most of which can be associated with one of the following functions: formation of extracellular matrix; operation of the immune system; vascularisation; An excess of granulation tissue (caro luxurians) is informally referred to as hypergranulation or "proud flesh". [4]

Hypergranulation, also known as “proud flesh,” is defined as an excessive accumulation of granulation tissue in a wound defect. Hypergranulation is a relatively common phenomenon in wound healing and can occur throughout the healing process of both acute and chronic wounds. To understand the concept of hypergranulation, it is necessary to know how a normally granulating wound behaves.. Hypergranulation tissue, also known as proud flesh, is a common complication that can occur during the wound healing process. It manifests as an excessive growth of granulation tissue beyond the wound margins, often protruding above the skin surface. This abnormal tissue growth can impede the normal healing process and lead to delayed wound.


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Doctors aren’t really sure what causes hypergranulation. An allergic reaction, trauma to the wound site, or an infection frequently happens before hypergranulation starts. Doctors believe hypergranulation might be a response to these factors but aren’t sure why some people’s bodies react that way. [2] X Research source Typically, when a wound fails to heal, the problem is a lack of granulated.. Search from 11,466 Proud Flesh stock photos, pictures and royalty-free images from iStock. For the first time, get 1 free month of iStock exclusive photos, illustrations, and more.